When we turn that two-part verb into a noun (the breakup) or an adjective (the breakup process), we write it as either hyphenated or as one word.  A good dictionary shows which. 
Verb: It runs on.  Noun: That's a run-on.  Adjective: a run-on sentence
Verb: I am paid up.   Noun: [not a noun]   Adjective: a paid-up account
Verb: I put it on.  Noun: It's a put-on, a joke. Adjective: a put-on accent
Verb: I pick it up. Noun: An 8:00 pickup  Adjective: a pickup game
Verb: I'll take off. Noun: The plane's takeoff Adjective: a takeoff delay
Verb: You set it up. Noun: Directions for setup   Adjective: a setup deadline
Verb: Look out!  Noun: He's our lookout.  Adjective: the lookout perch
Verb: Pay off the loan. Noun: Here's the payoff. Adjective: the payoff amount
Verb: I run away. Noun: He's a runaway. Adjective: runaway inflation
Verb: I run away. Noun: He's a runaway. Adjective: runaway inflation
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